Case Study

Pfizer – Antimicrobial Innovative Vaccines

Company Pfizer Inc., United States
Sub category of Industry R&D Pharma
Category of commitment Research & Science
Which product(s) Vaccines
Key focus Early-stage R&D, Late-stage R&D

Health needs

Pfizer has made significant and substantial investments in vaccine R&D to develop new vaccines and to support several vaccines already in clinical usage. It has been clearly demonstrated that bacterial vaccines significantly reduce AMR by preventing infection in the first place thus reducing the need to use antibiotics. In addition, bacterial vaccines if and when used to immunize large sections of a population also reduce the spread of AMR bacteria in the community through herd immunity.

Initiative’s objective

The program aims to prevent initial infection by developing new vaccines. This will consequently reduce antibiotic use and the spread of AMR.

Initiative’s description

Pfizer Vaccines in Late – Stage Development

In 2015, Pfizer began enrolling patients in a Phase 2 clinical trial of our investigational Staphylococcus aureus vaccine, designed to prevent this widespread but increasingly drug-resistant bacterium. In addition, enrolment is complete in the Phase 2 program for the Pfizer Clostridium difficile vaccine, aimed at the bacteria responsible for nearly a half million infections resulting in 29,000 US deaths in 2011. Prevention would reduce this disease impact and the need to treat the infections with antibiotics hence reducing overall antibiotic use. Both of these vaccine candidates have received Fast Track designation from the FDA

Pfizer Vaccines in Early – Stage Development In early stage development is a vaccine for protection against Group B Streptococcus (GBS). Treatment guidelines advise that GBS-colonized women should receive intrapartum antibiotic prophylaxis to prevent GBS disease in the neonate. Up to a million plus women each year are treated in this fashion.  The potential impact of antibiotic prophylaxis on both the microbiome of the newborn and the emergence of AMR is unknown; however, a vaccine against GBS would reduce the need for prophylactic antibiotic use and the potential for AMR.